Dr Anil Kumar Teotia, Sr Principal Scientific Officer, Dr. Prasad Thota, Scientific Officer from Microbiology Department of Indian Pharmacopoeia Commission (IPC) visited to Brussels, Belgium to attend two days Symposium on “Pyrogen testing 2.0: Ethical. Evolving and Eco-friendly” for Implementing safe, rapid, state-of-the art and sustainable non-animal approaches worldwide on 25 & 26/2/26 at Albert Borschette Conference Centre (CCAB) Jointly organized by European Directorate for the Quality of Medicines & Health Care (EDQM) and European Partnership for Alternative Approaches to Animal Testing (EPAA), during these 02 days Officials from IPC updated on the implementation of the Rabbit Pyrogen Test (RPT) RPT phase-out strategy across Europe; explored the challenges and solutions encountered during the transition to Monocyte Activation Test (MAT) MAT; explored the status of recombinant reagents for use in the bacterial endotoxins test (BET);updated on how other pharmacopoeias and regulatory frameworks outside Europe have adapted in response to the Ph. Eur.’s initiative; perspectives from regulators, industry, and international stakeholders on the future of animal-free pyrogenicity testing has been observed. Total, more than 100 Delegates participated from 30 Countries across the world in this symposium. Key outcomes for IPC to include a concept on “Recombinant reagents for BET” as a guidance in Indian Pharmacopoeia for its future adaptation by Indian Pharmaceutical Industries for Implementing safe, state-of-the-art and sustainable non-animal approaches in RPT.